Metreleptin Subcutaneous and Naloxegol Oxalate
Determining the interaction of Metreleptin Subcutaneous and Naloxegol Oxalate and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Metreleptin may reduce the blood levels of naloxegol, which may make the medication less effective in treating your condition. Contact your doctor if your symptoms worsen or your condition changes. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of naloxegol, which is primarily metabolized by the isoenzyme. When a single 25 mg dose of naloxegol was administered during multiple dosing of 600 mg once daily rifampin, a potent CYP450 3A4 inducer, naloxegol peak plasma concentration (Cmax) and systemic exposure (AUC) decreased by 76% and 89%, respectively. Simulations using physiologically based pharmacokinetic modeling suggest that when a single 25 mg dose of naloxegol is administered with 400 mg once daily efavirenz, a moderate CYP450 3A4 inducer, naloxegol exposures are similar to those after a 12.5 mg dose of naloxegol alone.
MANAGEMENT: The potential for diminished therapeutic effects of naloxegol should be considered when prescribed with inducers of CYP450 3A4. Pharmacologic effects of naloxegol should be monitored more closely whenever an inducer is added to or withdrawn from therapy, and alternative treatment considered if an interaction is suspected.
- "Product Information. Movantik (naloxegol)." Astra-Zeneca Pharmaceuticals, Wilmington, DE.
Generic Name: metreleptin
Brand name: Myalept
Synonyms: Metreleptin
Generic Name: naloxegol
Brand name: Movantik
Synonyms: Naloxegol
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Metreleptin Subcutaneous-Naloxone
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- Metreleptin Subcutaneous-Naloxone Auto-Injection
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- Metreleptin Subcutaneous-Naloxone Injection
- Metreleptin Subcutaneous-Naloxone nasal
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