Metreleptin Subcutaneous and Skyla IUD
Determining the interaction of Metreleptin Subcutaneous and Skyla IUD and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Treatment with metreleptin may alter the blood levels and effects of levonorgestrel. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. You may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Treatment with metreleptin, a recombinant analog of human leptin, may affect the pharmacokinetics of drugs that are primarily metabolized by CYP450 isoenzymes. In leptin-deficient obese mice, administration of leptin has been shown to alter the hepatic levels of some CYP450 isoenzymes.
MANAGEMENT: Caution is advised when metreleptin is prescribed to patients receiving drugs with a narrow therapeutic index that are substrates of CYP450 isoenzymes, such as macrolide immunosuppressants, oral contraceptives, cyclosporine, theophylline, and warfarin. Clinical and laboratory monitoring are recommended following the initiation, discontinuation or change of dosage of metreleptin, and the individual dosage of the concomitant agents adjusted as needed.
- "Product Information. Myalept (metreleptin)." Bristol-Myers Squibb, Princeton, NJ.
Generic Name: metreleptin
Brand name: Myalept
Synonyms: Metreleptin
Generic Name: levonorgestrel
Brand name: Skyla, Kyleena, Liletta, Mirena, Aftera, EContra EZ, EContra One-Step, Fallback Solo, My Choice, My Way, New Day, Next Choice One Dose, Opcicon One-Step, Plan B One-Step, React, Take Action, My Way, Next Choice
Synonyms: Skyla
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Metreleptin Subcutaneous-Skyrizi
- Metreleptin Subcutaneous-Skyrizi (150 MG Dose)
- Metreleptin Subcutaneous-Skyrizi Injection
- Metreleptin Subcutaneous-Skyrizi topical
- Metreleptin Subcutaneous-Sleep Aid
- Metreleptin Subcutaneous-Sleep Aid Tablets
- Skyla IUD-MetroCream
- Skyla IUD-Metrocream Topical
- Skyla IUD-MetroGel
- Skyla IUD-MetroGel (Metronidazole Cream, Gel, and Lotion)
- Skyla IUD-MetroGel (Metronidazole Gel and Cleansing Lotion)
- Skyla IUD-MetroGel Pump