Metreleptin Subcutaneous and Tacrolimus Extended-Release Tablets
Determining the interaction of Metreleptin Subcutaneous and Tacrolimus Extended-Release Tablets and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Treatment with metreleptin may alter the blood levels and effects of tacrolimus. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. You may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Treatment with metreleptin, a recombinant analog of human leptin, may affect the pharmacokinetics of drugs that are primarily metabolized by CYP450 isoenzymes. In leptin-deficient obese mice, administration of leptin has been shown to alter the hepatic levels of some CYP450 isoenzymes.
MANAGEMENT: Caution is advised when metreleptin is prescribed to patients receiving drugs with a narrow therapeutic index that are substrates of CYP450 isoenzymes, such as macrolide immunosuppressants, oral contraceptives, cyclosporine, theophylline, and warfarin. Clinical and laboratory monitoring are recommended following the initiation, discontinuation or change of dosage of metreleptin, and the individual dosage of the concomitant agents adjusted as needed.
- "Product Information. Myalept (metreleptin)." Bristol-Myers Squibb, Princeton, NJ.
Generic Name: metreleptin
Brand name: Myalept
Synonyms: Metreleptin
Generic Name: tacrolimus
Brand name: Astagraf XL, Envarsus XR, Prograf, Hecoria
Synonyms: Tacrolimus (oral and injection), Tacrolimus (Systemic)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Metreleptin Subcutaneous-Tacrolimus Granules for Suspension
- Metreleptin Subcutaneous-Tacrolimus Injection
- Metreleptin Subcutaneous-Tacrolimus Intravenous
- Metreleptin Subcutaneous-Tacrolimus oral and injection
- Metreleptin Subcutaneous-Tacrolimus Oral, Intravenous
- Metreleptin Subcutaneous-Tactinal
- Tacrolimus Extended-Release Tablets-MetroCream
- Tacrolimus Extended-Release Tablets-Metrocream Topical
- Tacrolimus Extended-Release Tablets-MetroGel
- Tacrolimus Extended-Release Tablets-MetroGel (Metronidazole Cream, Gel, and Lotion)
- Tacrolimus Extended-Release Tablets-MetroGel (Metronidazole Gel and Cleansing Lotion)
- Tacrolimus Extended-Release Tablets-MetroGel Pump