Metreleptin Subcutaneous and Trifluoperazine Hydrochloride

• Generic Name: metreleptin
• Dosage Forms: n.a.
• Other Brand Names: Myalept

Metreleptin injection is used together with a proper diet as replacement therapy to treat problems caused by leptin deficiency in patients with congenital or acquired generalized lipodystrophy.

Metreleptin is only available under a restricted distribution program called Myalept™ REMS program.

• Generic Name: trifluoperazine
• Dosage Forms: n.a.
• Other Brand Names: Stelazine

Treatment of schizophrenia.

American Psychiatric Association (APA) considers most atypical antipsychotic agents first-line drugs for management of the acute phase of schizophrenia (including first psychotic episodes). APA considers conventional antipsychotic agents first-line in patients with acute psychotic episodes who have been treated successfully in the past with, or who prefer, conventional agents.

Patients who do not respond to or tolerate one drug may be successfully treated with an agent from a different class or with a different adverse effect profile.

Short-term management of nonpsychotic anxiety in patients with generalized anxiety disorder.

Not established whether trifluoperazine is useful for the management of other nonpsychotic conditions in which anxiety or manifestations that mimic anxiety are evident (e.g., physical illness, organic mental conditions, agitated depression, character pathologies).

Because of the risks of toxicity, use only as an alternative to other less toxic anxiolytic agents (e.g., benzodiazepines) in most patients.

Efficacy not established for the management of behavioral complications in patients with mental retardation.