Mexiletine and Sodium Bicarbonate, Citric Acid, and Simethicone Effervescent Granule Pkt
Determining the interaction of Mexiletine and Sodium Bicarbonate, Citric Acid, and Simethicone Effervescent Granule Pkt and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Ask your doctor before using mexiletine together with sodium bicarbonate. Using these medications together can increase the blood levels or add to the side effects of mexiletine. This can cause nausea, seizures, numbness or tingling, tiredness, dizziness, a loss of consciousness, and a worsening irregular heartbeat. Use caution when driving, operating machinery, or performing other hazardous activities. Mexiletine may cause drowsiness and blurred vision. If you experience dizziness, drowsiness, or blurred vision, avoid these activities. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: Agents that alkalinize the urine reduce the plasma clearance of mexiletine. The result may be increased plasma mexiletine levels and possible toxicity. The clinical significance is unknown.
MANAGEMENT: It is recommended that such drugs be avoided during mexiletine therapy.
- Mitchell BG, Clements JA, Pottage A, Prescott LF "Mexiletine disposition: individual variation in response to urine acidification and alkalinisation." Br J Clin Pharmacol 16 (1983): 281-4
Generic Name: citric acid / simethicone / sodium bicarbonate
Brand name: EZ Gas II
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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