Mexiletine Hydrochloride and Nebivolol
Determining the interaction of Mexiletine Hydrochloride and Nebivolol and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Talk to your doctor before using mexiletine together with nebivolol. Both of these medications can slow your heart rate, and combining them may increase the effects. Excessive slowing of your heart rate can lead to serious or life-threatening cardiac complications including heart block and heart failure. Contact your doctor if you develop dizziness, lightheadedness, fainting, shortness of breath, chest pain, or heart palpitations during treatment with these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: The concomitant use of mexiletine with beta blockers may increase negative inotropic effects and potentiate effects on atrioventricular conduction time.
MANAGEMENT: Caution and monitoring for cardiac arrhythmias, bradycardia, and heart failure are recommended during concurrent therapy.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- "Product Information. Bystolic (nebivolol)." Forest Pharmaceuticals, St. Louis, MO.
- Leopold G, Pabst J, Ungethum W, Buhring KU "Basic pharmacokinetics of bisoprolol, a new highly beta 1-selective adrenoceptor antagonist." J Clin Pharmacol 26 (1986): 616-21
Generic Name: mexiletine
Brand name: Mexitil
Synonyms: Mexiletine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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