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Mexiletine Hydrochloride and Phenytoin Oral Suspension

Determining the interaction of Mexiletine Hydrochloride and Phenytoin Oral Suspension and the possibility of their joint administration.

Check result:

Mexiletine Hydrochloride <> Phenytoin Oral Suspension

Relevance: 07.08.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using phenytoin together with mexiletine may decrease the effects of mexiletine. Contact your doctor if your condition changes. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Hydantoins may induce the hepatic metabolism of mexiletine. Plasma mexiletine levels and mexiletine effectiveness may be decreased.

MANAGEMENT: It is recommended that the antiarrhythmic effectiveness of mexiletine be monitored and that mexiletine dosage be increased as needed. Also, when hydantoin is withdrawn, the clinician should be aware of the risk of mexiletine toxicity.

References

Begg EJ, Chinwah PM, Webb C, Day RO, Wade DN "Enhanced metabolism of mexiletine after phenytoin administration." Br J Clin Pharmacol 14 (1982): 219-23

Mexiletine Hydrochloride

Generic Name: mexiletine

Brand name: Mexitil

Synonyms: Mexiletine

What is Mexiletine Hydrochloride?

Phenytoin Oral Suspension

Generic Name: phenytoin

Brand name: Dilantin, Phenytek, Dilantin Infatabs, Phenytoin Sodium, Prompt

Synonyms: Phenytoin

What is Phenytoin Oral Suspension?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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