Mexiletine Hydrochloride and Quin-G

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using mexiletine together with quiNIDine may increase the effects of mexiletine. Contact your doctor if you experience nausea, seizures, numbness or tingling, tiredness, dizziness, a loss of consciousness, and a worsening irregular heartbeat. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Quinidine may reduce the hepatic metabolism of mexiletine in extensive debrisoquine metabolizers. The mechanism is inhibition of CYP450 2D6. Serum mexiletine levels and risk of toxicity may be increased. The pharmacologic properties of these drugs may be additive and even though the concurrent use of quinidine and mexiletine has been beneficial in some patients, the risk of proarrhythmic effects may be increased.

MANAGEMENT: The patient should be monitored for clinical, laboratory, and electrocardiographic signs and symptoms of mexiletine toxicity after quinidine has been added to the regimen. Patients should be advised to notify their physician if they experience nausea, vomiting, dizziness, drowsiness, blurry vision, increased irregular heartbeat, numbness or tingling, seizures, or syncope.

Mexiletine Hydrochloride

Generic Name: mexiletine

Brand name: Mexitil

Synonyms: Mexiletine

What is Mexiletine Hydrochloride?

Quin-G

Generic Name: quinidine

Brand name: Quin-G, Cardioquin, Quinora, Quinidex Extentabs, Quinaglute Dura-Tabs, Quin-Release

Synonyms: n.a.

What is Quin-G?