Mexiletine Hydrochloride and Quinidex Extentabs
Determining the interaction of Mexiletine Hydrochloride and Quinidex Extentabs and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using mexiletine together with quiNIDine may increase the effects of mexiletine. Contact your doctor if you experience nausea, seizures, numbness or tingling, tiredness, dizziness, a loss of consciousness, and a worsening irregular heartbeat. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Quinidine may reduce the hepatic metabolism of mexiletine in extensive debrisoquine metabolizers. The mechanism is inhibition of CYP450 2D6. Serum mexiletine levels and risk of toxicity may be increased. The pharmacologic properties of these drugs may be additive and even though the concurrent use of quinidine and mexiletine has been beneficial in some patients, the risk of proarrhythmic effects may be increased.
MANAGEMENT: The patient should be monitored for clinical, laboratory, and electrocardiographic signs and symptoms of mexiletine toxicity after quinidine has been added to the regimen. Patients should be advised to notify their physician if they experience nausea, vomiting, dizziness, drowsiness, blurry vision, increased irregular heartbeat, numbness or tingling, seizures, or syncope.
- Duff HJ, Rahmberg M, Sheldon RS "Role of quinidine in the mexiletine-quinidine interaction: Electrophysiologic correlates of enhanced antiarrhythmic efficiency." J Cardiovasc Pharmacol 16 (1990): 685-92
- Duff HJ, Kolodgie FD, Roden DM, Woosley RL "Electropharmacologic synergism with mexiletine and quinidine." J Cardiovasc Pharmacol 8 (1986): 840-6
Generic Name: mexiletine
Brand name: Mexitil
Synonyms: Mexiletine
Generic Name: quinidine
Brand name: Quin-G, Cardioquin, Quinora, Quinidex Extentabs, Quinaglute Dura-Tabs, Quin-Release
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Mexiletine Hydrochloride-Quinidine
- Mexiletine Hydrochloride-Quinidine Controlled-Release Tablets
- Mexiletine Hydrochloride-Quinidine Extended Release Tablets
- Mexiletine Hydrochloride-Quinidine Gluconate
- Mexiletine Hydrochloride-Quinidine Injection
- Mexiletine Hydrochloride-Quinidine Oral, Injection, Intramuscular
- Quinidex Extentabs-Mexitil
- Quinidex Extentabs-MG 217 Topical
- Quinidex Extentabs-MG Plus Protein
- Quinidex Extentabs-MG217 Medicated Tar
- Quinidex Extentabs-Mg217 Sal-Acid Topical
- Quinidex Extentabs-Mi-Acid