Mexiletine Hydrochloride and Sodium Citrate and Citric Acid
Determining the interaction of Mexiletine Hydrochloride and Sodium Citrate and Citric Acid and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Ask your doctor before using mexiletine together with sodium citrate. Using these medications together can increase the blood levels or add to the side effects of mexiletine. This can cause nausea, seizures, numbness or tingling, tiredness, dizziness, a loss of consciousness, and a worsening irregular heartbeat. Use caution when driving, operating machinery, or performing other hazardous activities. Mexiletine may cause drowsiness and blurred vision. If you experience dizziness, drowsiness, or blurred vision, avoid these activities. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: Agents that alkalinize the urine reduce the plasma clearance of mexiletine. The result may be increased plasma mexiletine levels and possible toxicity. The clinical significance is unknown.
MANAGEMENT: It is recommended that such drugs be avoided during mexiletine therapy.
- Mitchell BG, Clements JA, Pottage A, Prescott LF "Mexiletine disposition: individual variation in response to urine acidification and alkalinisation." Br J Clin Pharmacol 16 (1983): 281-4
Generic Name: mexiletine
Brand name: Mexitil
Synonyms: Mexiletine
Generic Name: citric acid / sodium citrate
Brand name: Bicitra, Cytra-2, Liqui-Dual Citra, Oracit, Shohl's Solution, Virtrate-2
Synonyms: Citric acid and sodium citrate
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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- Mexiletine Hydrochloride-Sodium Edecrin
- Mexiletine Hydrochloride-Sodium Ferric Gluconate
- Mexiletine Hydrochloride-Sodium ferric gluconate complex
- Sodium Citrate and Citric Acid-Mexitil
- Sodium Citrate and Citric Acid-MG 217 Topical
- Sodium Citrate and Citric Acid-MG Plus Protein
- Sodium Citrate and Citric Acid-MG217 Medicated Tar
- Sodium Citrate and Citric Acid-Mg217 Sal-Acid Topical
- Sodium Citrate and Citric Acid-Mi-Acid