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Mexitil and Rimactane

Determining the interaction of Mexitil and Rimactane and the possibility of their joint administration.

Check result:

Mexitil <> Rimactane

Relevance: 26.11.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using rifAMPin together with mexiletine may decrease the effects of mexiletine. Contact your doctor if your condition changes. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor

Professional:

MONITOR: Rifampin may decrease the plasma concentrations of mexiletine by inducing its CYP450 hepatic metabolism.

MANAGEMENT: Patients receiving both drugs should be monitored for inadequate response to mexiletine. Mexiletine dosage should be increased as necessary.

References

Venkatesan K "Pharmacokinetic drug interactions with rifampicin." Clin Pharmacokinet 22 (1992): 47-65
Pentikainen PJ, Koivula IH, Hiltunen HA "Effect of rifampicin treatment on the kinetics of mexiletine." Eur J Clin Pharmacol 23 (1982): 261-6

Mexitil

Generic Name: mexiletine

Brand name: Mexitil

Synonyms: n.a.

What is Mexitil?

Rimactane

Generic Name: rifampin

Brand name: Rifadin, Rifadin IV, Rimactane

Synonyms: n.a.

What is Rimactane?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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