Micafungin Intravenous and Nifedical XL
Determining the interaction of Micafungin Intravenous and Nifedical XL and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Coadministration with micafungin may increase the plasma concentrations of nifedipine. The exact mechanism of interaction is unknown but may involve inhibition of nifedipine metabolism, since micafungin has been shown to be a weak inhibitor of CYP450 3A in vitro. According to micafungin product labeling, nifedipine systemic exposure (AUC) and peak plasma concentration (Cmax) were increased by 18% and 42%, respectively, in the presence of micafungin at steady state compared to nifedipine alone. The clinical significance of these alterations is unknown.
- "Product Information. Mycamine (micafungin)." Fujisawa, Deerfield, IL.
Generic Name: micafungin
Brand name: Mycamine
Synonyms: Micafungin
Generic Name: nifedipine
Brand name: Adalat CC, Afeditab CR, Nifediac CC, Nifedical XL, Procardia, Procardia XL, Adalat
Synonyms: Nifedical XL (Oral)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Micafungin Intravenous-Nifedipine
- Micafungin Intravenous-Nifedipine Capsules
- Micafungin Intravenous-Nifedipine Extended-Release Tablets
- Micafungin Intravenous-Niferex
- Micafungin Intravenous-Niferex Elixir
- Micafungin Intravenous-Night Cast R Topical
- Nifedical XL-Micafungin Sodium
- Nifedical XL-Micardis
- Nifedical XL-Micardis HCT
- Nifedical XL-Micatin
- Nifedical XL-Micatin (Miconazole (Vaginal))
- Nifedical XL-Micatin (Miconazole Cream and Ointment)