Micafungin Intravenous and Onmel

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Coadministration with micafungin may increase the plasma concentrations of itraconazole. The exact mechanism of interaction is unknown but may involve inhibition of itraconazole metabolism, since micafungin has been shown to be a weak inhibitor of CYP450 3A in vitro. According to micafungin product labeling, itraconazole systemic exposure (AUC) and peak plasma concentration (Cmax) were increased by 22% and 11%, respectively, in the presence of micafungin at steady state, compared to itraconazole alone. The clinical significance of these alterations is unknown.

Micafungin Intravenous

Generic Name: micafungin

Brand name: Mycamine

Synonyms: Micafungin

What is Micafungin Intravenous?

Onmel

Generic Name: itraconazole

Brand name: Onmel, Sporanox, Sporanox PulsePak, Tolsura

Synonyms: n.a.

What is Onmel?