Micafungin Intravenous and Rapamune

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using sirolimus together with micafungin may increase the effects of sirolimus. Contact your doctor if you experience fast heart rate, fever, chills, body aches, flu symptoms, breathing problems, cough, chest tightness, pale skin, easy bruising or bleeding, weakness, or pain or burning when you urinate. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with micafungin may increase the serum concentrations of sirolimus. The exact mechanism of interaction is unknown but may involve inhibition of sirolimus metabolism, since micafungin has been shown to be a weak inhibitor of CYP450 3A in vitro. According to micafungin product labeling, sirolimus systemic exposure (AUC) was increased by 21% in the presence of micafungin at steady state compared to sirolimus alone. No effect on sirolimus Cmax was observed.

MANAGEMENT: Due to the narrow therapeutic index of sirolimus, pharmacologic response and sirolimus blood levels should be closely monitored following initiation or discontinuation of micafungin therapy in patients who are stabilized on their antirejection regimen, and the sirolimus dosage adjusted accordingly. Patients should be monitored for potential signs and symptoms of sirolimus toxicity such as fever, infection, diarrhea, hypokalemia, anemia, thrombocytopenia, leukopenia, and hyperlipidemia.

Micafungin Intravenous

Generic Name: micafungin

Brand name: Mycamine

Synonyms: Micafungin

What is Micafungin Intravenous?

Rapamune

Generic Name: sirolimus

Brand name: Rapamune

Synonyms: n.a.

What is Rapamune?