Micafungin Intravenous and Sporanox (Itraconazole Oral Solution)
Determining the interaction of Micafungin Intravenous and Sporanox (Itraconazole Oral Solution) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Coadministration with micafungin may increase the plasma concentrations of itraconazole. The exact mechanism of interaction is unknown but may involve inhibition of itraconazole metabolism, since micafungin has been shown to be a weak inhibitor of CYP450 3A in vitro. According to micafungin product labeling, itraconazole systemic exposure (AUC) and peak plasma concentration (Cmax) were increased by 22% and 11%, respectively, in the presence of micafungin at steady state, compared to itraconazole alone. The clinical significance of these alterations is unknown.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- "Product Information. Mycamine (micafungin)." Fujisawa, Deerfield, IL.
Generic Name: micafungin
Brand name: Mycamine
Synonyms: Micafungin
Generic Name: itraconazole
Brand name: Sporanox, Onmel, Sporanox PulsePak, Tolsura
Synonyms: Sporanox
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Micafungin Intravenous-Sporanox Capsules
- Micafungin Intravenous-Sporanox injection
- Micafungin Intravenous-Sporanox PulsePak
- Micafungin Intravenous-Sportsmed Topical
- Micafungin Intravenous-Spravato
- Micafungin Intravenous-Spravato (56 MG Dose)
- Sporanox (Itraconazole Oral Solution)-Micafungin Sodium
- Sporanox (Itraconazole Oral Solution)-Micardis
- Sporanox (Itraconazole Oral Solution)-Micardis HCT
- Sporanox (Itraconazole Oral Solution)-Micatin
- Sporanox (Itraconazole Oral Solution)-Micatin (Miconazole (Vaginal))
- Sporanox (Itraconazole Oral Solution)-Micatin (Miconazole Cream and Ointment)