Miconazole Buccal mucosa and Mycobutin

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Concomitant administration of oral miconazole may increase the plasma levels of rifabutin and the risk of adverse effects. The possible mechanism of this interaction is inhibition of CYP450 3A4. In addition, rifabutin may increase the metabolism and decrease the plasma levels of miconazole due to induction of CYP450 enzymes. The clinical significance of this interaction is unknown because systemic absorption from buccal and oral gel dosage forms is significantly lower than with parenteral administration.

Miconazole Buccal mucosa

Generic Name: miconazole

Brand name: Oravig, Monistat IV, Oravig

Synonyms: Miconazole oral (buccal), Miconazole (Oral)

What is Miconazole Buccal mucosa?

Mycobutin

Generic Name: rifabutin

Brand name: Mycobutin

Synonyms: n.a.

What is Mycobutin?