Miconazole oral buccal and Sunmark Loratadine
Determining the interaction of Miconazole oral buccal and Sunmark Loratadine and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Ketoconazole has been reported to inhibit the metabolism of loratadine. Area under the plasma concentration time curve (AUC) has increased 180% for loratadine and 56% for its active metabolite. The mechanism of this interaction is inhibition of CYP450 3A4 metabolism by ketoconazole. No adverse effects or cardiotoxicity were observed in this study. Loratadine and cetirizine appear to be safe for use with ketoconazole. Terfenadine and astemizole should not be used with ketoconazole.
- Woosley R, Carrow WR "Analysis of potential adverse drug reactions--a case of mistaken identity." Am J Cardiol 74 (1994): 208-9
- "Product Information. Nizoral (ketoconazole)." Janssen Pharmaceutica, Titusville, NJ.
- Yumibe N, Huie K, Chen KJ, Clement RP, Cayen MN "Identification of human liver cytochrome P450s involved in the microsomal metabolism of the antihistaminic drug loratadine." Int Arch Allery Immunol 207 (1995): 420
- "Product Information. Claritin (loratadine)." Schering Laboratories, Kenilworth, NJ.
Generic Name: miconazole
Brand name: Oravig, Monistat IV, Oravig
Synonyms: Miconazole oral (buccal), Miconazole (Oral)
Generic Name: loratadine
Brand name: Alavert, Claritin, Claritin Reditab, Clear-Atadine, Dimetapp ND, Ohm Allergy Relief, QlearQuil All Day & Night, Tavist ND, Wal-itin
Synonyms: Loratadine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Miconazole oral buccal-Sunmark Miconazole 7
- Miconazole oral buccal-Sunmark Nicotine Lozenge
- Miconazole oral buccal-Sunmark Nicotine Polacrilex
- Miconazole oral buccal-Sunmark Sleep Aid
- Miconazole oral buccal-Sunosi
- Miconazole oral buccal-Supartz
- Sunmark Loratadine-Miconazole Powder
- Sunmark Loratadine-Miconazole Spray and Spray Powder
- Sunmark Loratadine-Miconazole topical
- Sunmark Loratadine-Miconazole vaginal
- Sunmark Loratadine-Miconazole, zinc oxide, and white petrolatum Topical application
- Sunmark Loratadine-MiCort-HC