Microgestin Fe 1/20 and Roflumilast

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Ethinyl estradiol may increase the blood levels and effects of roflumilast. You may be more likely to experience side effects of roflumilast such as diarrhea, nausea, abdominal pain, weight loss, headache, insomnia, depression, and anxiety. Let your doctor know if side effects become excessive or intolerable. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with oral contraceptives may increase the systemic exposure to roflumilast and its pharmacologically active N-oxide metabolite. In 20 healthy adult volunteers, administration of a single 500 mcg oral dose of roflumilast following repeated doses of a fixed combination oral contraceptive containing 0.075 mg gestodene and 0.03 mg ethinyl estradiol to steady state resulted in a 38% increase in roflumilast peak plasma concentration (Cmax) and a 51% increase in systemic exposure (AUC). The Cmax of roflumilast N-oxide was reduced by 12%, while AUC increased by 14%.

MANAGEMENT: Caution is advised when roflumilast is used in combination with oral contraceptives containing ethinyl estradiol and/or gestodene. Treatment with roflumilast should be re-evaluated if an interaction is suspected and persistent intolerability occurs. Patients should be advised to contact their doctor if they experience increased frequency and/or severity of side effects such as diarrhea, nausea, abdominal pain, weight loss, headache, insomnia, depression, and anxiety.

Microgestin Fe 1/20

Generic Name: ethinyl estradiol / norethindrone

Brand name: Blisovi 24 Fe, Blisovi Fe 15/30, Blisovi Fe 1/20, Estrostep Fe, Gildess 24 Fe, Gildess Fe 15/30, Gildess Fe 1/20, Junel Fe 15/30, Junel Fe 1/20, Junel Fe 24, Larin 24 Fe, Larin Fe 15/30, Larin Fe 1/20, Lo Loestrin Fe, Loestrin 24 Fe, Loestrin Fe 15/30, Loestrin Fe 1/20, Lomedia 24 Fe, Microgestin 24 Fe, Microgestin Fe 15/30, Microgestin Fe 1/20, Tarina Fe 1/20, Taytulla, Tilia Fe, Tri-Legest Fe, Blisovi 24 Fe, Femcon Fe, Kaitlib FE, Lo Minastrin Fe, Microgestin 24 Fe, Norinyl 1+35, Ortho-Novum 7/7/7, Tri-Norinyl, Zenchent, femhrt 05 mg/25 mcg, Fyavolv, Jevantique Lo, Jinteli, Femcon Fe, Generess FE, Loestrin 1/20, Ovcon 35, Brevicon

Synonyms: n.a.

What is Microgestin Fe 1/20?

Roflumilast

Generic Name: roflumilast

Brand name: Daliresp

Synonyms: n.a.

What is Roflumilast?