Midazolam Hydrochloride and Prednisolone ODT
Determining the interaction of Midazolam Hydrochloride and Prednisolone ODT and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Certain corticosteroids may decrease the plasma concentration of some benzodiazepines. Limited data are available for midazolam and triazolam. The mechanism is related to induction of hepatic cytochrome P450 enzymes responsible for benzodiazepine metabolism. The clinical significance may depend on the dosage and duration of corticosteroid therapy and be of greater importance with oral administration of benzodiazepines.
- Villikka K, Kivisto KT, Neuvonen PJ "The effect of dexamethasone on the pharmacokinetics of triazolam." Pharmacol Toxicol 83 (1998): 135-8
- Nakajima M, Suzuki T, Sasaki T, Yokoi T, Hosoyamada A, Yamamoto T, Kuroiwa Y "Effects of chronic administration of glucocorticoid on midazolam pharmacokinetics in humans." Ther Drug Monit 21 (1999): 507-13
Generic Name: midazolam
Brand name: Versed, Nayzilam
Synonyms: Midazolam
Generic Name: prednisolone
Brand name: Flo-Pred, Millipred, Millipred DP, Orapred, Orapred ODT, Pediapred, Veripred 20, Prelone, Hydeltra-TBA, Hydeltrasol, Key-Pred, Cotolone, Depo-Predate, Predicort-50, Predalone 50, Predacort 50, Predate-50, Predaject-50, Pred-Ject-50, Key-Pred SP, Medicort, Predicort RP, Pri-Cortin 50, Predcor, Bubbli-Pred, AsmalPred Plus, Flo-Pred Oral Suspension
Synonyms: Prednisolone, PrednisoLONE (Systemic)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Midazolam Hydrochloride-Prednisolone ophthalmic
- Midazolam Hydrochloride-Prednisolone Ophthalmic Suspension
- Midazolam Hydrochloride-Prednisolone Oral Solution
- Midazolam Hydrochloride-Prednisolone Orally Disintegrating Tablets
- Midazolam Hydrochloride-Prednisolone Sodium Phosphate
- Midazolam Hydrochloride-Prednisolone Sodium Phosphate eent
- Prednisolone ODT-Midazolam injection
- Prednisolone ODT-Midazolam Injection Hospira
- Prednisolone ODT-Midazolam nasal
- Prednisolone ODT-Midazolam Nasal Spray
- Prednisolone ODT-Midazolam Syrup
- Prednisolone ODT-Midodrine