Midazolam nasal and PCE Dispertab

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Erythromycin may increase the blood levels of midazolam. This can increase the risk and/or severity of side effects including excessive drowsiness, motor impairment, amnesia, anxiety, hallucinations, and breathing difficulties (especially if you have a respiratory disorder such as asthma or obstructive sleep apnea). Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. You should avoid the use of alcohol while being treated with midazolam. Avoid driving or operating hazardous machinery until you know how the medication affects you, and do not exceed the dosage or frequency of use prescribed by your doctor. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: The macrolide antibiotics clarithromycin and erythromycin may increase and prolong the CNS effects of certain benzodiazepines. The mechanism is inhibition of CYP450 3A4 hepatic oxidation of the benzodiazepines. The effect appears most pronounced with oral midazolam and triazolam. A single dose of midazolam coadministered with oral clarithromycin (500 mg twice daily for 7 days) increased the midazolam AUC by 174% after IV midazolam administration and 600% after oral midazolam administration. Administration of midazolam via the oromucosal route may bypass pre-systemic elimination and lead to an interaction similar to that observed when midazolam is administered intravenously rather than orally. Lorazepam, oxazepam, and temazepam are hepatically conjugated and are not expected to interact. Azithromycin and dirithromycin do not inhibit CYP450 isoenzymes.

MANAGEMENT: The use of oral midazolam or triazolam in combination with clarithromycin or erythromycin should generally be avoided. Some authorities consider the use of oral midazolam with clarithromycin contraindicated. Patients receiving triazolam or IV midazolam in combination with erythromycin or clarithromycin should be monitored for excessive or prolonged sedation. Dose adjustment of the benzodiazepine should be considered. Some authorities suggest a dose reduction of midazolam during long-term IV infusion of up to 50% of the initial dose followed by careful titration. Non-interacting benzodiazepines or antimicrobials may be considered as alternatives.

Midazolam nasal

Generic Name: midazolam

Brand name: Versed, Nayzilam

Synonyms: Midazolam

What is Midazolam nasal?

PCE Dispertab

Generic Name: erythromycin

Brand name: EES. Granules, EES-400 Filmtab, EryPed 200, EryPed 400, Ery-Tab, Erythrocin Lactobionate, Erythrocin Stearate Filmtab, PCE Dispertab, E. E. S, EryPed, Erythrocin, Erythromycin Filmtabs, Erythromycin Lactobionate - IV

Synonyms: PCE Dispertab (Oral), PCE, PCE (Oral)

What is PCE Dispertab?