Midazolam nasal and Verelan PM

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using midazolam together with verapamil may increase the effects of midazolam. Contact your doctor if you experience extreme drowsiness, confusion, muscle weakness, slurred speech, tremors, a slow heartbeat, shallow breathing, feeling light-headed, fainting, or seizure (blackout or convulsions). If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Diltiazem and verapamil both have been reported to increase peak plasma concentration and to prolong the elimination half-life of midazolam. The mechanism probably is related to an increase in the bioavailability and a decrease in the plasma clearance of midazolam. Diltiazem, verapamil, midazolam, and triazolam all appear to be metabolized by the CYP450 (3A4) enzyme.

MANAGEMENT: If diltiazem or verapamil must be used with midazolam or triazolam, close observation for increased and prolonged midazolam or triazolam effect is recommended. Some investigators have suggested that midazolam dosage be reduced by at least 50% in patients who are receiving diltiazem or verapamil. Other investigators have suggested that triazolam be avoided in patients receiving diltiazem.

Midazolam nasal

Generic Name: midazolam

Brand name: Versed, Nayzilam

Synonyms: Midazolam

What is Midazolam nasal?

Verelan PM

Generic Name: verapamil

Brand name: Verelan PM, Calan, Calan SR, Isoptin SR, Verelan, Isoptin, Isoptin IV, Covera-HS

Synonyms: n.a.

What is Verelan PM?