Midodrine and Phenergan

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using promethazine together with midodrine can increase the side effects of promethazine. Contact your doctor if you experience tension, restlessness, insomnia, and anxiety. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Limited data suggest that midodrine may potentiate the risk of akathisia associated with promethazine. The mechanism is unknown but may involve competitive inhibition of CYP450 2D6 metabolism. In nine healthy volunteers, six experienced akathisia after receiving a single 10 mg oral dose of midodrine followed 60 minutes later by a 25 mg intravenous dose of promethazine, compared to four after receiving promethazine and placebo. No subject experienced akathisia following midodrine alone. The severity of akathisia was also significantly greater with the combination than with promethazine alone.

MANAGEMENT: Patients treated with midodrine and promethazine in combination should be monitored for signs and symptoms of akathisia such as tension, restlessness, insomnia, and anxiety. One or both drugs may need to be discontinued if akathisia occurs.

Midodrine

Generic Name: midodrine

Brand name: Proamatine, Orvaten

Synonyms: n.a.

What is Midodrine?

Phenergan

Generic Name: promethazine

Brand name: Phenergan, Phenadoz, Promethegan

Synonyms: n.a.

What is Phenergan?