Mifepristone Tablets (For High Blood Sugar) and Navelbine Injection
Determining the interaction of Mifepristone Tablets (For High Blood Sugar) and Navelbine Injection and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:MiFEPRIStone may increase the blood levels and effects of vinorelbine, even after you have stopped taking miFEPRIStone for a while. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Based on in vitro inhibition data, coadministration with mifepristone may increase the plasma concentrations of drugs that are substrates of the CYP450 3A4 isoenzyme. The mechanism is decreased clearance due to inhibition of CYP450 3A4 activity by mifepristone.
MANAGEMENT: Caution is advised if mifepristone must be used concomitantly with medications that undergo metabolism by CYP450 3A4, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever mifepristone is added to or withdrawn from therapy. Because mifepristone is eliminated slowly from the body, drug interactions may be observed for a prolonged period following discontinuation (approximately 2 to 3 weeks if mifepristone had been administered chronically to steady state).
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- He K, Woolf TF, Hollenberg PF "Mechanism-based inactivation of cytochrome P-450-3A4 by mifepristone (RU486)." J Pharmacol Exp Ther 288 (1999): 791-7
- "Product Information. Mifeprex (mifepristone)" Danco Laboratories, New York, NY.
- Cerner Multum, Inc. "Australian Product Information." O 0
Generic Name: mifepristone
Brand name: Korlym, Mifeprex
Synonyms: Mifepristone
Generic Name: vinorelbine
Brand name: Navelbine
Synonyms: Navelbine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Mifepristone Tablets (For High Blood Sugar)-Naxen
- Mifepristone Tablets (For High Blood Sugar)-Nayzilam
- Mifepristone Tablets (For High Blood Sugar)-Nazarin HC
- Mifepristone Tablets (For High Blood Sugar)-Nazil Ofteno
- Mifepristone Tablets (For High Blood Sugar)-Nebcin
- Mifepristone Tablets (For High Blood Sugar)-Nebivolol
- Navelbine Injection-Migalastat
- Navelbine Injection-Migalastat Hydrochloride
- Navelbine Injection-Migergot
- Navelbine Injection-Migergot Suppository
- Navelbine Injection-Miglitol
- Navelbine Injection-Miglustat