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Minizide and Procardia XL

Determining the interaction of Minizide and Procardia XL and the possibility of their joint administration.

Check result:

Minizide <> Procardia XL

Relevance: 20.03.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Before taking prazosin, tell your doctor if you also use NIFEdipine. You may need dose adjustments or special tests in order to safely take both medications together. This combination may have additive effects on lowering your blood pressure. You should take prazosin at bedtime and notify your doctor if you feel dizzy or faint. It is important that you tell your healthcare provider about all other medications that you are using including vitamins and herbs. Do not stop using your medications without first talking to your doctor first.

Professional:

MONITOR: The hypotensive effects of nifedipine and alpha-adrenergic blockers may be additive. The proposed mechanism is additive vasodilatory effects. Postural hypotension may occur.

MANAGEMENT: Hemodynamic responses should be monitored during coadministration, especially during the first few weeks of therapy. Patients should be advised to take the alpha-blocker at bedtime and to notify their physician if they experience dizziness or syncope while awake.

References

"Product Information. Xatral (alfuzosin)." Sanofi-Synthelabo Canada Inc, Markham, ON.
Jee LD, Opie LH "Acute hypotensive response to nifedipine added to prazosin in treatment of hypertension." Br Med J 287 (1983): 1514
Pool JL "Combination antihypertensive therapy with terazosin and other antihypertensive agents: results of clinical trials." Am Heart J 122 (1991): 926-31
Kiss I, Farsang C "Nifedipine-prazosin interaction in patients with essential hypertension." Cardiovasc Drugs Ther 3 (1989): 413-5
Elliott HL, Pasanisi F, Meredith PA, Reid JL "Acute hypotensive response to nifedipine added to prazosin." Br Med J (Clin Res Ed) 288 (1984): 238-9

Minizide

Generic Name: polythiazide / prazosin

Brand name:

Synonyms: n.a.

What is Minizide?

Procardia XL

Generic Name: nifedipine

Brand name: Adalat CC, Procardia, Procardia XL, Afeditab CR, Nifediac CC, Nifedical XL, Adalat

Synonyms: n.a.

What is Procardia XL?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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