Minocin (Minocycline Injection) and Theophylline Liquid
Determining the interaction of Minocin (Minocycline Injection) and Theophylline Liquid and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using minocycline together with theophylline may increase the effects of theophylline. You should contact your doctor if you experience nausea, vomiting, diarrhea, headache, restlessness, insomnia, seizures, or an irregular heartbeat. You may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration of a tetracycline may decrease theophylline plasma clearance and increase theophylline levels. The mechanism is unknown. Data are available for minocycline, tetracycline, and doxycycline, but are conflicting in some cases. This interaction appears to be more problematic if a tetracycline is administered for more than five days. Patients with chronic obstructive pulmonary disease, congestive heart failure, or cirrhosis may have slower theophylline clearance rates; therefore, they may be at greater risk of developing theophylline toxicity.
MANAGEMENT: If these drugs are given concurrently, close clinical and laboratory monitoring of response and tolerance is recommended. Patients should be advised to notify their physician if they experience any signs of theophylline toxicity including nausea, vomiting, diarrhea, headache, restlessness, insomnia, seizures, or irregular heartbeats. It may be necessary to reduce theophylline dosage.
- Gotz VP, Ryerson GG "Evaluation of tetracycline on theophylline disposition in patients with chronic obstructive airways disease." Drug Intell Clin Pharm 20 (1986): 694-6
- McCormack JP, Reid SE, Lawson LM "Theophylline toxicity induced by tetracycline." Clin Pharm 9 (1990): 546-9
- Upton RA "Pharmacokinetic interactions between theophylline and other medication (Part I)." Clin Pharmacokinet 20 (1991): 66-80
Generic Name: minocycline
Brand name: Dynacin, Minocin, Minocin PAC, Solodyn, Ximino, Minolira, Vectrin, Myrac
Synonyms: Minocin
Generic Name: theophylline
Brand name: Elixophyllin, Theo-24, Respbid, T-Phyl, Aerolate III, Slo-Bid Gyrocaps, Slo-Phyllin, Theobid, Theo-Dur, Theolair, Theovent, Bronkodyl, Theo-X, Theo-Time, Theochron, Slo-Phyllin 125, Theoclear LA-130, Aerolate JR, Theolair-SR, Theoclear LA-260, Quibron-T, Quibron-T/SR, Uniphyl, Uni-Dur, Aerolate SR, Slo-Phyllin 80, Theoclear-80, Theo-Dur Sprinkles, Theosol-80, Asmalix, Aquaphyllin, Truxophyllin, Slo-Phyllin 250, TheoCap
Synonyms: Theophylline
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Minocin (Minocycline Injection)-Theophylline Oral Solution
- Minocin (Minocycline Injection)-Theophylline Sustained-Release Capsules
- Minocin (Minocycline Injection)-Theophylline Sustained-Release Tablets
- Minocin (Minocycline Injection)-Thera-D 2000
- Minocin (Minocycline Injection)-Thera-Gesic
- Minocin (Minocycline Injection)-Thera-Gesic Plus
- Theophylline Liquid-Minocin (Minocycline Oral Suspension)
- Theophylline Liquid-Minocin Injection
- Theophylline Liquid-Minocin Intravenous
- Theophylline Liquid-Minocin PAC
- Theophylline Liquid-Minocycline
- Theophylline Liquid-Minocycline (Systemic)