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Mintezol and Uniphyl

Determining the interaction of Mintezol and Uniphyl and the possibility of their joint administration.

Check result:

Mintezol <> Uniphyl

Relevance: 05.08.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using theophylline together with thiabendazole may increase the effects of theophylline. Contact your doctor if you experience nausea, vomiting, insomnia, tremors, restlessness, uneven heartbeats, and seizure (convulsions). If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Theophylline toxicity has been reported during concomitant administration of theophylline and thiabendazole. Decreases in clearance have been noted up to nine days after discontinuation of thiabendazole. One small study reported a decrease in clearance of 66%. The proposed mechanism is inhibition of hepatic metabolism by thiabendazole.

MANAGEMENT: Clinical monitoring of patient response and tolerance and serum theophylline levels is recommended. Patients should be advised to report any signs of theophylline toxicity including nausea, vomiting, diarrhea, headache, restlessness, insomnia, or irregular heartbeat to their physicians. The theophylline dosage may require reduction or alternatives agents could be considered during thiabenzole therapy.

References

Sugar AM, Kearns PJ, Haulk AA, Rushing JL "Possible thiabendazole-induced theophylline toxicity." Am Rev Respir Dis 122 (1980): 501-3
Lew G, Murray WE, Lane JR, Haeger E "Theophylline-thiabendazole drug interaction." Clin Pharm 8 (1989): 225-7
Upton RA "Pharmacokinetic interactions between theophylline and other medication (Part II)." Clin Pharmacokinet 20 (1991): 135-50
Schneider D, Gannon R, Sweeney K, Shore E "Theophylline and antiparasitic drug interactions: a case report and study of the influence of thiabendazole and mebendazole on theophylline pharmacokinetics in adult." Chest 97 (1990): 84-7

Mintezol

Generic Name: thiabendazole

Brand name:

Synonyms: n.a.

What is Mintezol?

Uniphyl

Generic Name: theophylline

Brand name: Elixophyllin, Theo-24, Respbid, T-Phyl, Aerolate III, Slo-Bid Gyrocaps, Slo-Phyllin, Theobid, Theo-Dur, Theolair, Theovent, Bronkodyl, Theo-X, Theo-Time, Theochron, Slo-Phyllin 125, Theoclear LA-130, Aerolate JR, Theolair-SR, Theoclear LA-260, Quibron-T, Quibron-T/SR, Uniphyl, Uni-Dur, Aerolate SR, Slo-Phyllin 80, Theoclear-80, Theo-Dur Sprinkles, Theosol-80, Asmalix, Aquaphyllin, Truxophyllin, Slo-Phyllin 250, TheoCap

Synonyms: Uniphyl (Oral)

What is Uniphyl?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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