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Mintox and Neoral

Determining the interaction of Mintox and Neoral and the possibility of their joint administration.

Check result:

Mintox <> Neoral

Relevance: 24.10.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using aluminum hydroxide together with cycloSPORINE may decrease the effects of cycloSPORINE. CycloSPORINE should be administered at least two hours before or six hours after aluminum hydroxide. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

ADJUST DOSING INTERVAL: The blood concentrations of orally administered cyclosporine were reported to have decreased rapidly in a pediatric patient who had been administered cyclosporine combined with dried aluminum hydroxide gel. One study (n=46) concluded that the blood concentrations of cyclosporine were affected by coadministration with dried aluminum hydroxide gel. The proposed mechanism of this interaction is adsorption or complex formation by aluminum. Other aluminum salts may interact in a similar manner.

MANAGEMENT: Oral cyclosporine should be administered 2 hours before or 6 hours after the aluminum salt in order to avoid this potential interaction. The patient's therapeutic response should be monitored.

References

Ichisawa M, Ohta I, Suzuki R, et al. "The effect of dried aluminum hydroxide gel on the blood concentration of cyclosporine-A." Jpn J Hosp Pharm 23 (1997): 407-13

Mintox

Generic Name: aluminum hydroxide / magnesium hydroxide / simethicone

Brand name: Almacone, Gelusil, Mag-al Plus, Mi-Acid, Milantex, Mintox, Mylanta Maximum Strength, Rulox, Mylanta Fast Acting, Mylanta DS Fast Acting, Maalox Plus, Masanti DS, Masanti II, Masanti, Alamag Plus, Mi-Acid II, Almacone-2, Mintox Plus, Mylagen, Mylagen-II, Magaant, Ri-Mox Plus, Rulox Plus, Di-Gel, Ri-Gel II, Uni-Lan, Uni-Lan II, Urban, Urban DS, Maldroxal Plus, Maalox Plus Extra Strength, Tempo, Mylanta, Maalox Max, Maalox, Aldroxicon I, Aldroxicon II, Maalox Antacid Antigas Regular Strength, Mintox Extra Strength, Mintox Maximum Strength, Comfort Gel Original, Comfort Gel Extra Strength, Mylanta Maximum Strength Cherry, Maalox Max Wild Berry, Maalox Advanced Maximum Strength, Milantex Maximum Strength, Maalox Advanced Regular Strength, Geri-Lanta, Mag-al Plus XS, Mylanta Maximum Strength Vanilla Caramel, Mi-Acid Maximum Strength, Di-Gel Liquid

Synonyms: n.a.

What is Mintox?

Neoral

Generic Name: cyclosporine

Brand name: Gengraf, Neoral, Sandimmune, Sandimmune

Synonyms: Neoral (Capsules, Modified)

What is Neoral?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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