Mipomersen Subcutaneous and Orphenadrine Citrate

• Generic Name: mipomersen
• Dosage Forms: n.a.
• Other Brand Names: Kynamro

Mipomersen injection is used together with a proper diet and other medicines to treat high cholesterol levels in patients with homozygous familial hypercholesterolemia (HoFH).

Mipomersen is only available through a restricted access program. Only doctors who are enrolled in the restricted program can write a prescription for mipomersen.

• Generic Name: orphenadrine
• Dosage Forms: n.a.
• Other Brand Names: Norflex, Banflex, Orphenate, Flexoject, Flexon, Mio-Rel, Myolin, Orfro, Norflex Injectable, Antiflex

Used alone or in combination with aspirin and caffeine as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute, painful musculoskeletal conditions.

If pharmacologic therapy is required for acute low back pain (usually a benign and self-limiting condition ), an analgesic (e.g., acetaminophen, NSAIA) generally is recommended. Skeletal muscle relaxants may be used alone or in combination with analgesics for short-term relief; however, consider high incidence of adverse effects (e.g., CNS effects). Use skeletal muscle relaxants with caution and weigh risks against benefits.

Various skeletal muscle relaxants appear to have comparable efficacy for low back pain relief.