Mirabegron and Provigil
Determining the interaction of Mirabegron and Provigil and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Coadministration with inducers of CYP450 3A4 and/or P-glycoprotein may decrease the plasma concentrations of mirabegron, which has been shown in vitro to be a substrate of the isoenzyme and efflux transporter. However, in vivo results indicate that these pathways may play a limited role in the overall elimination. In healthy study subjects, mirabegron peak plasma concentration (Cmax) and systemic exposure (AUC) decreased by less than 50% when a single 100 mg dose of mirabegron was administered following multiple dosing of rifampin 600 mg once daily. No dosage adjustment is recommended when mirabegron is administered in combination with rifampin and probably other CYP450 3A4/P-gp inducers.
- "Product Information. Myrbetriq (mirabegron)." Astellas Pharma US, Inc, Deerfield, IL.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Mirabegron-Provocholine
- Mirabegron-Proxacol
- Mirabegron-Prozac
- Mirabegron-Prozac (Fluoxetine Capsules and Tablets)
- Mirabegron-Prozac (Fluoxetine Solution)
- Mirabegron-Prozac Capsules
- Provigil-Miradyne-3
- Provigil-MiraLAX
- Provigil-Miranel AF (Miconazole (Vaginal))
- Provigil-Miranel AF (Miconazole Liquid)
- Provigil-Mirapex
- Provigil-Mirapex ER