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Mirapex and Reglan

Determining the interaction of Mirapex and Reglan and the possibility of their joint administration.

Check result:

Mirapex <> Reglan

Relevance: 05.02.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Talk to your doctor before using metoclopramide together with pramipexole. Metoclopramide may reduce the effectiveness of pramipexole. In addition, using these medications together may increase the risk or severity of side effects like drowsiness, low blood pressure, dizziness, and lightheadedness. These side effects may occur with either medication alone and are most likely to be seen at the beginning of treatment, following a dose increase, or when treatment is restarted after an interruption. Let your doctor know if you develop these symptoms and they do not go away after a few days or they become troublesome. Avoid driving or operating hazardous machinery until you know how the medications affect you, and use caution when getting up from a sitting or lying position. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Agents with central antidopaminergic activity such as metoclopramide may antagonize the pharmacologic effects of dopamine agonists. In addition, the central nervous system depressant and hypotensive effects of these agents may be additively or synergistically increased when taken together.

MANAGEMENT: Concomitant use of dopamine agonists with antidopaminergic agents should generally be avoided. If coadministration is necessary, patients should be alerted to the possibility of excessive drowsiness and monitored for potentially diminished therapeutic response to their dopaminergic therapy. Patients treated for Parkinson's disease should generally avoid antidopaminergic agents, since they may cause extrapyramidal reactions.

References

"Product Information. Requip (ropinirole)." SmithKline Beecham, Philadelphia, PA.
"Product Information. Norprolac (quinagolide)." Ferring Inc, North York, IA.
"Product Information. Geodon (ziprasidone)." Pfizer US Pharmaceuticals, New York, NY.
"Product Information. Dostinex (cabergoline)." Pharmacia and Upjohn, Kalamazoo, MI.
"Product Information. Mirapex (pramipexole)." Boehringer Ingelheim, Ridgefield, CT.
"Product Information. Zyprexa (olanzapine)." Lilly, Eli and Company, Indianapolis, IN.
"Product Information. Permax (pergolide)." Athena Neurosciences Inc, South San Francisco, CA.
"Product Information. Parlodel (bromocriptine)." Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
"Product Information. Reglan (metoclopramide)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
Yahr MD, Duvoisin RC "Drug therapy of parkinsonism." N Engl J Med 287 (1972): 20-4
Mims RB, Scott CL, Modebe O, Bethune JE "Inhibition of L-dopa-induced growth hormone stimulation by pyridoxine and chlorpromazine." J Clin Endocrinol Metab 40 (1975): 256-9
Robbins RJ, Kern PA, Thompson TL "Interactions between thioridazine and bromocriptine in a patient with a prolactin-secreting pituitary adenoma." Am J Med 76 (1984): 921-3
"Product Information. Risperdal (risperidone)." Janssen Pharmaceutica, Titusville, NJ.
Weingarten JC, Thompson TL "The effect of thioridazine on prolactinoma growth in a schizophrenic man: case report." Gen Hosp Psychiatry 7 (1985): 364-6
"Product Information. Seroquel (quetiapine)." Zeneca Pharmaceuticals, Wilmington, DE.

Mirapex

Generic Name: pramipexole

Brand name: Mirapex, Mirapex ER

Synonyms: n.a.

What is Mirapex?

Reglan

Generic Name: metoclopramide

Brand name: Reglan, Metozolv ODT

Synonyms: n.a.

What is Reglan?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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