Mitigare and Prefest

• Generic Name: colchicine
• Dosage Forms: capsule
• Other Brand Names: Colcrys, Mitigare

Mitigare affects the way the body responds to uric acid crystals, which reduces swelling and pain.

Because Mitigare was developed prior to federal regulations requiring FDA review of all marketed drug products, not all uses for this medicine have been approved by the FDA.

The Colcrys brand of colchicine is FDA-approved to treat or prevent gout in adults, and to treat a genetic condition called Familial Mediterranean Fever in adults and children who are at least 4 years old.

The Mitigare brand of colchicine is FDA-approved to prevent gout flares in adults.

Generic forms of colchicine have been used to treat or prevent attacks of gout, or to treat symptoms of Behcets syndrome (such as swelling, redness, warmth, and pain).

Mitigare is not a cure for gouty arthritis or Behcets syndrome, and it will not prevent these diseases from progressing. This medicine should not be used as a routine pain medication for other conditions.

Mitigare may also be used for purposes not listed in this medication guide.

• Generic Name: estradiol / norgestimate
• Dosage Forms: tablets
• Other Brand Names: Prefest, Ortho-Prefest

Estradiol is a form of estrogen, a female sex hormone that regulates many processes in the body.

Norgestimate is a form of progesterone, a female hormone important for regulating ovulation and menstruation.

Prefest is a combination medicine used to treat menopause symptoms such as hot flashes and vaginal changes, and to prevent osteoporosis (bone loss) in menopausal women.

Prefest may also be used for purposes not listed in this medication guide.