Mitomycin and Rubex

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using DOXOrubicin together with mitoMYcin may affect your heart and lead to increased side effects. Contact your doctor if you experience signs of congestive heart failure such as difficulty breathing, fluid retention, chest pain, and irregular heartbeats. If your doctor does prescribe these medications together you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Limited data suggest that mitomycin C and doxorubicin have synergistic cardiotoxicity. In one study of 91 patients who failed doxorubicin therapy and who were then given mitomycin C, 14 (15.3%) developed heart failure, compared with 3 of 89 (3.4%) in a control group of patients who received doxorubicin without mitomycin C.

MANAGEMENT: Until more data are available, careful monitoring of heart function (noninvasive testing with echocardiography and/or multigated blood pool scanning and ECG) is recommended when these drugs are given together or sequentially.

Mitomycin

Generic Name: mitomycin

Brand name: Mutamycin

Synonyms: MitoMYcin (Systemic)

What is Mitomycin?

Rubex

Generic Name: doxorubicin

Brand name: Adriamycin, Adriamycin RDF, Rubex, Adriamycin PFS

Synonyms: Doxorubicin, DOXOrubicin (Conventional)

What is Rubex?