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Mitomycin Intravenous and Soltamox

Determining the interaction of Mitomycin Intravenous and Soltamox and the possibility of their joint administration.

Check result:

Mitomycin Intravenous <> Soltamox

Relevance: 26.07.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Ask your doctor before using mitoMYcin together with tamoxifen. Taking these medications together can cause damage to the kidneys. Talk to your doctor if you have any questions or concerns. Your doctor may already be aware of the risks, but has determined that this is the best course of treatment for you and has taken appropriate precautions and is monitoring you closely for any potential complications. Kidney function and drug levels in the blood may be monitored with blood tests during treatment. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Tamoxifen significantly increases the risk of microangiopathic hemolytic uremic syndrome (HUS) associated with mitomycin C. HUS can be fatal in up to 50% of affected patients. The mechanism of this interaction is not known, but may involve a combination of subclinical endothelial damage induced by mitomycin C and a thrombotic effect on platelets caused by tamoxifen.

MANAGEMENT: Some experts advise that tamoxifen should be avoided during or immediately after mitomycin C therapy unless the patient is carefully monitored with frequent and regular CBCs as well as serum BUN and creatinine measurements.

References

Ellis PA, Luckitt J, Treleaven J, Smith IE "Haemolytic uraemic syndrome in a patient with lung cancer: further evidence for a toxic interaction between mitomycin-C and tamoxifen." Clin Oncol (R Coll Radiol) 8 (1996): 42-3
Montes A, Powles TJ, O'Brien ME, Ashley SE, Luckit J, Treleaven J "A toxic interaction between mitomycin C and tamoxifen causing the haemolytic uraemic syndrome." Eur J Cancer 29a (1993): 1854-7
O'Brien ME, Casey S, Treleaven J, Powles TJ "Use of erythropoietin in the management of the haemolytic uraemic syndrome induced by mitomycin C/tamoxifen." Eur J Cancer 30a (1994): 894-5

Mitomycin Intravenous

Generic Name: mitomycin

Brand name: Mutamycin

Synonyms: Mitomycin, MitoMYcin (Systemic)

What is Mitomycin Intravenous?

Soltamox

Generic Name: tamoxifen

Brand name: Soltamox, Nolvadex

Synonyms: n.a.

What is Soltamox?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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