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Mivacron and Xylocaine (Cardiac)

Determining the interaction of Mivacron and Xylocaine (Cardiac) and the possibility of their joint administration.

Check result:

Mivacron <> Xylocaine (Cardiac)

Relevance: 05.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using mivacurium together with lidocaine can prolong the effects of mivacurium. You should be closely monitored for prolong breathing cessation and respiratory paralysis after use of lidocaine. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Lidocaine may enhance the effect of neuromuscular blocking agents. The mechanism is not known, but may include inhibition of acetylcholine release from presynaptic neurons.

MANAGEMENT: Patients should be closely monitored for increased and/or prolonged neuromuscular blockade and apnea during and after concomitant therapy.

References

Harrah MD, Way WL, Katzung BG "The interaction of d-tubocurarine with antiarrhythmic drugs." Anesthesiology 33 (1970): 406-10
Miller RD, Way WL "Inhibition of succinylcholine-induced increased intragastric pressure by nondepolarizing muscle relaxants and lidocaine." Anesthesiology 34 (1971): 185-8
Fukuda S, Wakuta K, Ishikawa T, Oshita S, Sakabe T, Takeshita H "Lidocaine modifies the effect of succinylcholine on muscle oxygen consumption in dogs." Anesth Analg 66 (1987): 325-8
Matsuo S, Rao DBS, Chaudry I, Foldes FF "Interaction of muscle relaxants and local anesthetics at the neuromuscular junction." Anesth Analg 57 (1978): 580-7
Pouttu J, Tuominen MK, Rosenberg PH "Cardiovascular responses caused by the combination of lidocaine and vecuronium in the induction of general anaesthesia." Acta Anaesthesiol Scand 32 (1988): 549-52
Bruckner J, Thomas KC, Bikhazi GB, Foldes FF "Neuromuscular drug interactions of clinical importance." Anesth Analg 59 (1980): 678-82

Mivacron

Generic Name: mivacurium

Brand name: Mivacron

Synonyms: n.a.

What is Mivacron?

Xylocaine (Cardiac)

Generic Name: lidocaine

Brand name: UAD Caine, Xylocaine HCl, Xylocaine-MPF, Lidoject 1, Xylocaine Dental Cartridges, Lidoject 2, Xylocaine Duo-Trach Kit, Xylocaine HCl For Spinal, L-Caine, Dilocaine, Nervocaine, Truxacaine, Anestacaine

Synonyms: Lidocaine injection, Lidocaine (Systemic)

What is Xylocaine (Cardiac)?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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