Modafinil and Premarin (Conjugated Estrogens Tablets)
Determining the interaction of Modafinil and Premarin (Conjugated Estrogens Tablets) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Coadministration with modafinil (the racemate) or armodafinil (the R-enantiomer) may decrease the plasma concentrations of drugs that are substrates of the CYP450 3A4 isoenzyme. Modafinil and armodafinil are modest inducers of CYP450 3A4, and pharmacokinetic studies suggest that their effects may be primarily intestinal rather than hepatic. Thus, clinically significant interactions would most likely be expected with drugs that have low oral bioavailability due to significant intestinal CYP450 3A4-mediated first-pass metabolism (e.g., buspirone, cyclosporine, lovastatin, midazolam, saquinavir, simvastatin, sirolimus, tacrolimus, triazolam, calcium channel blockers). However, the potential for interaction should be considered with any drug metabolized by CYP450 3A4, especially given the high degree of interpatient variability with respect to CYP450-mediated metabolism. Pharmacologic response to these drugs may be altered and should be monitored more closely whenever modafinil or armodafinil is added to or withdrawn from therapy. Dosage adjustments may be required if an interaction is suspected.
- Doherty MM, Charman WN "The mucosa of the small intestine: how clinically relevant as an organ of drug metabolism?" Clin Pharmacokinet 41 (2002): 235-53
- Robertson P, Decory HH, Madan A, Parkinson A "In vitro inhibition and induction of human hepatic cytochrome P450 enzymes by modafinil." Drug Metab Dispos 28 (2000): 664-71
- Robertson P Jr, Hellriegel ET, Arora S, Nelson M "Effect of modafinil on the pharmacokinetics of ethinyl estradiol and triazolam in healthy volunteers." Clin Pharmacol Ther 71 (2002): 46-56
- "Product Information. Nuvigil (armodafinil)." Cephalon Inc, West Chester, PA.
- "Product Information. Provigil (modafinil)." Cephalon, Inc, West Chester, PA.
Generic Name: conjugated estrogens
Brand name: Enjuvia, Premarin, Premarin Intravenous, Cenestin
Synonyms: Premarin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Modafinil-Premarin (Estrogens (Conjugated/Equine, Topical))
- Modafinil-Premarin Cream
- Modafinil-Premarin Injection
- Modafinil-Premarin Intravenous
- Modafinil-Premarin Vaginal
- Modafinil-Premarin Vaginal Vaginal
- Premarin (Conjugated Estrogens Tablets)-Moderiba
- Premarin (Conjugated Estrogens Tablets)-Moduretic 5-50
- Premarin (Conjugated Estrogens Tablets)-Moexipril
- Premarin (Conjugated Estrogens Tablets)-Moexipril and Hydrochlorothiazide
- Premarin (Conjugated Estrogens Tablets)-Moexipril Hydrochloride
- Premarin (Conjugated Estrogens Tablets)-Mogamulizumab