Modafinil and Zovia 1/35

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using ethinyl estradiol together with modafinil may decrease the effectiveness of ethinyl estradiol. If you are using low-dose oral contraceptives you may have an increased risk of breakthrough bleeding and unintended pregnancy. You should discuss the use of alternative or additional methods of birth control with your healthcare provider. If you take hormone replacement for menopause, notify your doctor if you have decreased efficacy of your hormones such as increased hot flashes, vaginal dryness or menstrual problems. It is important that you tell your healthcare provider about all other medications that you are using including vitamins and herbs. Do not stop using your medications without first talking to your doctor first.

ADDITIONAL CONTRACEPTION RECOMMENDED: Coadministration with modafinil (the racemate) or armodafinil (the R-enantiomer) may decrease the plasma concentrations of ethinyl estradiol and other contraceptive hormones. The mechanism involves induction of CYP450 3A4-mediated metabolism by modafinil and armodafinil. In female volunteers treated chronically with an oral contraceptive containing ethinyl estradiol (0.035 mg) and norgestimate (0.18 to 0.25 mg), an 18% reduction in mean ethinyl estradiol systemic exposure (AUC) from baseline was observed in 16 subjects receiving modafinil (200 mg once daily for 7 days, then 400 mg for 21 days) compared to a 4% reduction in 18 subjects receiving placebo. The mean peak plasma concentration (Cmax) of ethinyl estradiol was also reduced by 11% versus 5% from baseline, respectively. The clinical significance of these alterations is unknown. In the study, pharmacodynamic effects as measured by plasma levels of FSH and LH showed no statistically significant differences between treatment groups before or after treatment with modafinil versus placebo. However, pharmacokinetic effects and interactions involving ethinyl estradiol are often subject to a high degree of interpatient variability, and the clinical significance may be increased in certain susceptible patients.

MANAGEMENT: Women using hormonal contraceptives (including depot and implantable contraceptives) should be advised of the risk of breakthrough bleeding and unintended pregnancy during concomitant therapy with modafinil or armodafinil. Alternative or additional methods of birth control are recommended during and for one month after treatment with modafinil or armodafinil. Intrauterine systems are unlikely to be significantly affected because of their local action. Input from a gynecologist or similar expert on adequate contraception, including emergency contraception, should be sought as needed.

Modafinil

Generic Name: modafinil

Brand name: Provigil

Synonyms: n.a.

What is Modafinil?

Zovia 1/35

Generic Name: ethinyl estradiol / ethynodiol

Brand name: Kelnor, Zovia 1/35, Zovia 1/50, Demulen 1/35, Demulen 1/50, Zovia 1/35e, Kelnor 1/50, Kelnor 1/35, Zovia 1/50e

Synonyms: Zovia 1/35E

What is Zovia 1/35?