Modafinil and Zykadia

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this interaction is not currently available.MONITOR: Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of ceritinib, which is a substrate of the isoenzyme. In 19 healthy subjects, administration of a single 750 mg dose of ceritinib with the potent CYP450 3A4 inducer rifampin (600 mg daily for 14 days) decreased ceritinib peak plasma concentration (Cmax) by 44% and systemic exposure (AUC) by 70%. Data are not available for ceritinib in combination with other, less potent CYP450 3A4 inducers. MANAGEMENT: Patients receiving ceritinib with CYP450 3A4 inducers should be monitored for potentially diminished pharmacologic response to ceritinib. Concomitant use should be avoided if an interaction is suspected. References "Product Information. Zykadia (ceritinib)." Novartis Pharmaceuticals, East Hanover, NJ.

MONITOR: Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of ceritinib, which is a substrate of the isoenzyme. In 19 healthy subjects, administration of a single 750 mg dose of ceritinib with the potent CYP450 3A4 inducer rifampin (600 mg daily for 14 days) decreased ceritinib peak plasma concentration (Cmax) by 44% and systemic exposure (AUC) by 70%. Data are not available for ceritinib in combination with other, less potent CYP450 3A4 inducers.

MANAGEMENT: Patients receiving ceritinib with CYP450 3A4 inducers should be monitored for potentially diminished pharmacologic response to ceritinib. Concomitant use should be avoided if an interaction is suspected.

Modafinil

Generic Name: modafinil

Brand name: Provigil

Synonyms: n.a.

What is Modafinil?

Zykadia

Generic Name: ceritinib

Brand name: Zykadia

Synonyms: n.a.

What is Zykadia?