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MorphaBond ER and Yohimbine

Determining the interaction of MorphaBond ER and Yohimbine and the possibility of their joint administration.

Check result:
MorphaBond ER <> Yohimbine
Relevance: 04.05.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

A double-blind, placebo-controlled study of patients with postoperative dental pain found that while yohimbine itself did not affect pain, the overall analgesic effect of morphine was significantly enhanced in the presence of yohimbine. The mechanism of interaction is unknown. Additional research involving other pain states is needed.

References
  • Gear RW, Gordon NC, Heller PH, Levine JD "Enhancement of morphine analgesia by the alpha(2)-adrenergic antagonist yohimbine." Neuroscience 66 (1995): 5-8
MorphaBond ER

Generic Name: morphine

Brand name: Arymo ER, Kadian, MorphaBond ER, Avinza, MS Contin, Duramorph PF, Infumorph, Mitigo, RMS, Roxanol

Synonyms: Morphabond ER

Yohimbine

Generic Name: yohimbine

Brand name:

Synonyms: Yohimbine (Oral)

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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