Motrin PM and Olaratumab

• Generic Name: diphenhydramine / ibuprofen
• Dosage Forms: tablet, coated
• Other Brand Names: Advil PM, Advil PM Liqui-Gels, Ibuprofen PM, Motrin PM

Diphenhydramine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose. Antihistamines can cause drowsiness, which can aid in the treatment of occasional sleep problems (insomnia).

Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID). Ibuprofen works by reducing hormones that cause inflammation and pain in the body.

Motrin PM is a combination medicine used to treat occasional insomnia associated with minor aches and pains.

Motrin PM is not for use in treating sleeplessness without pain, or sleep problems that occur often.

Motrin PM may also be used for purposes not listed in this medication guide.

• Generic Name: olaratumab
• Dosage Forms: n.a.
• Other Brand Names: Lartruvo

Olaratumab is a monoclonal antibody that blocks a certain type of cell receptor in the body that can affect tumor cell growth. Monoclonal antibodies are made to target and destroy only certain cells in the body, which may help slow or stop tumor growth.

Olaratumab is used in combination with another cancer medicine called doxorubicin, to treat adults with soft tissue sarcoma. Olaratumab is used when your condition cannot be treated with surgery or radiation.

Olaratumab was approved by the US Food and Drug Administration (FDA) on an "accelerated" basis. In clinical studies, olaratumab was shown to lengthen survival time. However, further studies are needed to determine if olaratumab is effective in larger numbers of patients with soft tissue sarcoma.

Olaratumab may also be used for purposes not listed in this medication guide.