Motrin PM and Pegvaliase-pqpz Subcutaneous

• Generic Name: diphenhydramine / ibuprofen
• Dosage Forms: tablet, coated
• Other Brand Names: Advil PM, Advil PM Liqui-Gels, Ibuprofen PM, Motrin PM

Diphenhydramine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose. Antihistamines can cause drowsiness, which can aid in the treatment of occasional sleep problems (insomnia).

Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID). Ibuprofen works by reducing hormones that cause inflammation and pain in the body.

Motrin PM is a combination medicine used to treat occasional insomnia associated with minor aches and pains.

Motrin PM is not for use in treating sleeplessness without pain, or sleep problems that occur often.

Motrin PM may also be used for purposes not listed in this medication guide.

• Generic Name: pegvaliase
• Dosage Forms: n.a.
• Other Brand Names: Palynziq

Pegvaliase-pqpz injection is used to lower phenylalanine levels in the blood in adults with phenylketonuria (PKU), who have uncontrolled blood phenylalanine levels with their current treatment.

Pegvaliase-pqpz is available only under a restricted distribution program called Palynziq™ REMS (Risk Evaluation and Mitigation Strategy) Program.