Drug search by name

Moxatag and Probenecid and colchicine

Determining the interaction of Moxatag and Probenecid and colchicine and the possibility of their joint administration.

Check result:

Moxatag <> Probenecid and colchicine

Relevance: 23.12.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Probenecid may increase the plasma concentrations and half-lives of penicillins. The mechanism is competitive inhibition by probenecid of the renal tubular secretion of penicillins. While this interaction is often exploited to enhance the antibacterial effect of penicillins, toxicity may occur and should be considered if high penicillin dosages are administered intravenously.

References

Waller ES, Sharanevych MA, Yakatan GJ "The effect of probenecid on nafcillin disposition." J Clin Pharmacol 22 (1982): 482-9
Allen MB, Fitzpatrick RW, Barratt A, Cole RB "The use of probenecid to increase the serum amoxycillin levels in patients with bronchiectasis." Respir Med 84 (1990): 143-6
Sutherland R, Croydon EA, Rolinson GN "Amoxycillin: a new semi-synthetic penicillin." Br Med J 3 (1972): 13-6
Sommers DK, Schoeman HS "Drug interactions with urate excretion in man?" Eur J Clin Pharmacol 32 (1987): 499-502
Shanson DC, McNabb R, Hajipieris P "The effect of probenecid on serum amoxycillin concentrations up to 18 hours after a single 3g oral dose of amoxycillin: possible implications for preventing endocarditis." J Antimicrob Chemother 13 (1984): 629-32
Gibaldi M, Schwartz MA "Apparent effect of probenecid on the distribution of penicillins in man." Clin Pharmacol Ther 9 (1968): 345-9

Moxatag

Generic Name: amoxicillin

Brand name: Moxatag, Amoxil, Trimox

Synonyms: n.a.

What is Moxatag?

Probenecid and colchicine

Generic Name: colchicine / probenecid

Brand name:

Synonyms: Probenecid and colchicine (Oral)

What is Probenecid and colchicine?

+ Add a drug Remove all

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

The list of popular interactions