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Multi-Delyn and Renvela (Sevelamer Tablets)

Determining the interaction of Multi-Delyn and Renvela (Sevelamer Tablets) and the possibility of their joint administration.

Check result:

Multi-Delyn <> Renvela (Sevelamer Tablets)

Relevance: 23.11.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using sevelamer together with multivitamin may decrease the effects of multivitamin. Multivitamin should be administered at least 4 hours before sevelamer. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

ADJUST DOSING INTERVAL: Bile acid sequestrants and the phosphate binder, sevelamer, can decrease the absorption of fat-soluble vitamins A, D, E, and K. In non-clinical safety studies, rats administered colesevelam at doses greater than 30-fold the projected human clinical dose developed hemorrhage in association with vitamin K deficiency. In a crossover study involving healthy subjects, coadministration of sevelamer with calcitriol resulted in a significant reduction in bioavailability for calcitriol (calcitriol with sevelamer vs calcitriol alone: AUC 137 pg*h/mL vs 318 pg*h/mL and Cmax 40.1 pg/mL vs 49.7 pg/mL, respectively).

MANAGEMENT: Oral vitamin supplements should be administered at least 4 hours before colesevelam and either 1 hour before or 4 to 6 hours after other bile acid sequestrants and sevelamer.

References

Peirce D, Hossack S, Poole L, et.al "The effect of sevelamer carbonate and lanthanum carbonate on the pharmacokinetics of oral calcitriol." Nephrol Dial Transplant 26 (2011): 1615-21
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
"Product Information. Rocaltrol (calcitriol)." Roche Laboratories, Nutley, NJ.
Cerner Multum, Inc. "Australian Product Information." O 0
"Product Information. Welchol (colesevelam)" Daiichi Sankyo, Inc., Parsippany, NJ.

Multi-Delyn

Generic Name: multivitamin

Brand name: Antibiotic Plus Pain Relief, CVS Antibiotic Plus, Double Antibiotic + Pain Relief, EQ Antibiotic + Pain Relief, EQL Antibiotic + Pain Relief, Centamin, Centrum Cardio, Centrum Flavor Burst, Centrum MultiGummies, Centrum Performance, Centrum Silver Ultra Men's, Centrum Silver Ultra Women's, Centrum Silver, Centrum Ultra Men's, Centrum Ultra Women's, Centrum, Corvite 150, CyFolex, Diatx Zn, Drinkables Fruits and Vegetables, Drinkables MultiVitamins, Encora, FeRiva, FeRiva 21/7, FeRivaFA, Ferralet 90, Foltrin, Freedavite, Fusion Plus, Fusion, Geri-Freeda, Geriation, Geritol Complete, Geritol Extend, Geritol Tonic, Glutofac-MX, Gynovite Plus, Hemocyte Plus, Hi-Kovite, Iberet-500, K-Tan Plus, Monocaps, Multilex, Multilex-T&M, Myadec, NeoMultivite, Nicadan, NicAzel Forte, NuFera, Nutrimin-Plus, Ocuvel, Ocuvite Adult 50+, Ocuvite Extra, Ocuvite Lutein, Ocuvite, One A Day Cholesterol Plus, One A Day Energy, One A Day Essential, One A Day Maximum, One A Day Men's 50+ Advantage, One A Day Men's Health Formula, One A Day Teen Advantage for Her, One A Day Teen Advantage for Him, One A Day Weight Smart Advanced, One A Day Womenâ€™s Active Mind & Body, One A Day Womenâ€™s, One A Day Women's 50+ Advantage, One-Daily/Iron, Optivite PMT, PreserVision AREDS 2 Formula + Multivitamin, PreserVision AREDS, PreserVision Lutein, Quflora FE, Quintabs, Quintabs-M Iron-Free, Quintabs-M, Replace Without Iron, Replace, Repliva 21/7, Strovite, Strovite Forte, Strovite Plus, Thera-Tabs M, Theramill Forte, TL-HEM 150, Ultra Freeda A-Free, Ultra Freeda Iron-Free, Ultra Freeda With Iron, Viactiv Calcium Flavor Glides, Viactiv Flavor Glides, Viactiv for Teens, Viactiv With Calcium, Viactiv, Virt-FeFA Plus, Vitafol, Xtramins, Yelets, Infuvite Adult, MVI. -12, Natrol SAMe, Protegra, Vicon Forte, Stress-600, Thera-Tabs, AquADEKs, Pedia Tri-Vite Drops, Tri-Vita, Vitamax Pediatric

Synonyms: n.a.

What is Multi-Delyn?

Renvela (Sevelamer Tablets)

Generic Name: sevelamer

Brand name: Renagel, Renvela

Synonyms: Renvela

What is Renvela (Sevelamer Tablets)?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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