Multivitamin with iron and fluoride and Mycophenolate Mofetil Injection
Determining the interaction of Multivitamin with iron and fluoride and Mycophenolate Mofetil Injection and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Limited data suggest that the oral bioavailability of mycophenolic acid (MPA) may be decreased by concomitant administration of iron preparations. The mechanism of interaction has not been established, and available data are conflicting. In an early study with seven healthy subjects, administration of 1 gram of mycophenolate mofetil (MMF) with a single 1050 mg dose of sustained-release ferrous sulfate (equivalent to 210 mg of elemental iron) decreased mean MPA peak plasma concentration (Cmax) and systemic exposure (AUC) by 94% and 91%, respectively, compared to administration of MMF alone. However, several subsequent studies, including some conducted in kidney transplant patients, reported no significant changes in MPA pharmacokinetics during coadministration with iron at the same time or up to four hours apart. The reasons for the discrepancy have not been determined. In vitro, there was no evidence of complexation between iron and MMF or MPA. No precautions appear necessary to avoid potential interaction; however, it may be advisable to monitor pharmacologic response and blood levels closely if an iron product is added to stabilized mycophenolate therapy.
- Gelone DK, Park JM, Lake KD "Lack of an effect of oral iron administration on mycophenolic acid pharmacokinetics in stable renal transplant recipients." Pharmacotherapy 27 (2007): 1272-8
- Morii M, Ueno K, Ogawa A, Kato R, Yoshimura H, Wada K, Hashimoto H, Takada M, Tanaka K, Nakatani T, Shibakawa M "Impairment of mycophenolate mofetil absorption by iron ion." Clin Pharmacol Ther 68 (2000): 613-6
- "Product Information. CellCept (mycophenolate mofetil)." Roche Laboratories, Nutley, NJ.
- Mudge DW, Atcheson B, Taylor PJ, et al. "The effect of oral iron administration on mycophenolate mofetil absorption in renal transplant recipients: a randomized, controlled trial." Transplantation 77 (2004): 206-9
- Lidgate D, Brandl M, Holper M, Abubakari A, Wu X "Influence of ferrous sulfate on the solubility, partition coefficient, and stability of mycophenolic acid and the ester mycophenolate mofetil." Drug Dev Ind Pharm 28 (2002): 1275-83
- "Product Information. Myfortic (mycophenolic acid)." Novartis Pharmaceuticals, East Hanover, NJ.
- Lorenz M, Wolzt M, Weigel G, et al. "Ferrous sulfate does not affect mycophenolic acid pharmacokinetics in kidney transplant patients." Am J Kidney Dis 43 (2004): 1098-103
- Ducray PS, Banken L, Gerber M, Boutouyrie B, Zandt H "Absence of an interaction between iron and mycophenolate mofetil absorption." Br J Clin Pharmacol 62 (2006): 492-5
Generic Name: multivitamin with iron and fluoride
Brand name: Berocca, Primaplex, Vi-Daylin/F Plus Iron, Vi-Daylin/F ADC with Iron, Tri-Vi-Flor with Iron, Poly Vitamin with Fluoride with Iron, Multi Vita Bets and Fluoride and Iron, PhluoriVit with Iron, Escavite D, Escavite LQ, Quflora FE, Poly-Vi-Flor
Synonyms: Multi Vitamin, Iron and Fluoride
Generic Name: mycophenolate mofetil
Brand name: Cellcept, Myfortic, MMF
Synonyms: Mycophenolate, Mycophenolate mofetil (oral/injection)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Multivitamin with iron and fluoride-Mycophenolate Mofetil Injection Solution
- Multivitamin with iron and fluoride-Mycophenolate Mofetil Oral Suspension
- Multivitamin with iron and fluoride-Mycophenolate mofetil oral/injection
- Multivitamin with iron and fluoride-Mycophenolate Mofetil Tablets
- Multivitamin with iron and fluoride-Mycophenolate sodium
- Multivitamin with iron and fluoride-Mycophenolate Suspension
- Mycophenolate Mofetil Injection-Multivitamins
- Mycophenolate Mofetil Injection-Multivitamins and minerals
- Mycophenolate Mofetil Injection-Multivitamins Capsules and Tablets
- Mycophenolate Mofetil Injection-Multivitamins Liquid
- Mycophenolate Mofetil Injection-Multivitamins with fluoride
- Mycophenolate Mofetil Injection-Multivitamins with Minerals, Folic Acid, and Omega-3 Fatty Acids