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Multivitamin with iron and fluoride and Trientine

Determining the interaction of Multivitamin with iron and fluoride and Trientine and the possibility of their joint administration.

Check result:
Multivitamin with iron and fluoride <> Trientine
Relevance: 10.11.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Trientine can bind to iron in the gastrointestinal tract. This may inactivate the iron and also interfere with the absorption of trientine into the bloodstream. The effectiveness of both medications may be reduced. To avoid or minimize the interaction, the dosing times of trientine and multivitamin with iron and fluoride (or any other iron-containing medication) should be separated by at least two hours. Talk to your doctor if you have any questions or concerns, or if you have trouble separating the dosing times. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

ADJUST DOSING INTERVAL: The oral bioavailability of trientine and iron or other minerals may be decreased during concurrent administration. The proposed mechanism is chelation of trientine by polyvalent cations, forming an insoluble complex that is poorly absorbed from the gastrointestinal tract.

MANAGEMENT: In general, mineral supplements and other products containing minerals should not be used in patients treated with trientine. However, iron deficiency may develop, particularly in children and menstruating or pregnant women. If necessary, iron may be given in short courses, provided that administration times are separated by at least two hours.

References
  • "Product Information. Syprine (trientine)." Aton Pharma, Lawrenceville, NJ.
Multivitamin with iron and fluoride

Generic Name: multivitamin with iron and fluoride

Brand name: Berocca, Primaplex, Vi-Daylin/F Plus Iron, Vi-Daylin/F ADC with Iron, Tri-Vi-Flor with Iron, Poly Vitamin with Fluoride with Iron, Multi Vita Bets and Fluoride and Iron, PhluoriVit with Iron, Escavite D, Escavite LQ, Quflora FE, Poly-Vi-Flor

Synonyms: Multi Vitamin, Iron and Fluoride

Trientine

Generic Name: trientine

Brand name: Syprine, Clovique

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

Interaction with food and lifestyle