Mycobutin and Telaprevir

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using rifabutin together with telaprevir is not recommended. Combining these medications may significantly increase the blood levels and effects of rifabutin. This may increase the risk of serious side effects including low white blood cell count and an eye condition known as uveitis, which causes inflammation and swelling of the middle layer of the eye and can lead to blindness. At the same time, rifabutin may cause the blood levels of telaprevir to decrease, which may reduce its effectiveness in treating hepatitis C. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Coadministration of rifabutin with boceprevir or telaprevir is expected to increase the plasma concentrations of rifabutin and its metabolite and decrease the plasma concentrations of the hepatitis C virus NS3/4A protease inhibitor. The proposed mechanism involves inhibition of rifabutin metabolism via CYP450 3A4 and, conversely, induction of boceprevir and telaprevir metabolism via the same isoenzyme. The interaction has not been specifically studied with either boceprevir or telaprevir, but has been reported with HIV protease inhibitors, resulting in increased systemic exposure (AUC) of rifabutin by 100% to 300% and that of its 25-O-desacetyl metabolite by 13- to 35-fold. Uveitis secondary to rifabutin toxicity has been reported in some cases. The effect of rifabutin on HIV protease inhibitors may vary. Rifabutin had negligible effects on some protease inhibitors but reduced the AUC of others such as indinavir, nelfinavir, and saquinavir by 30% to nearly 50%.

MANAGEMENT: Safe and effective dosages have not been established for the concomitant use of rifabutin with either boceprevir or telaprevir. Coadministration is not recommended.

Mycobutin

Generic Name: rifabutin

Brand name: Mycobutin

Synonyms: n.a.

What is Mycobutin?

Telaprevir

Generic Name: telaprevir

Brand name: Incivek

Synonyms: Telaprevir (Oral)

What is Telaprevir?