Mycophenolate Intravenous and Phenytoin Sodium, Prompt injection
Determining the interaction of Mycophenolate Intravenous and Phenytoin Sodium, Prompt injection and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:In vitro studies have shown that mycophenolic acid in concentrations up to 100 mcg/mL decreases protein binding of phenytoin from 90% to 87%. The clinical significance of this interaction is unknown. Decreased protein binding theoretically could lead to increased plasma phenytoin concentrations. However, clinical toxicity has not been reported. It may be appropriate to monitor more closely patients receiving phenytoin or other hydantoins with mycophenolic acid products.
- "Product Information. CellCept (mycophenolate mofetil)." Roche Laboratories, Nutley, NJ.
Generic Name: mycophenolate mofetil
Brand name: Cellcept, Myfortic, MMF
Synonyms: Mycophenolate mofetil (oral/injection), Mycophenolate
Generic Name: phenytoin
Brand name: Dilantin, Phenytoin Sodium, Prompt, Phenytek, Dilantin Infatabs
Synonyms: Phenytoin Sodium, Prompt (injection)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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