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Mycophenolate mofetil oral/injection and Titralac

Determining the interaction of Mycophenolate mofetil oral/injection and Titralac and the possibility of their joint administration.

Check result:

Mycophenolate mofetil oral/injection <> Titralac

Relevance: 26.09.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using calcium carbonate together with mycophenolate mofetil may decrease the effects of mycophenolate mofetil. You should separate the administration times of the medications by at least two hours. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

ADJUST DOSING INTERVAL: Coadministration with antacids may decrease the oral bioavailability of mycophenolic acid. The exact mechanism of interaction is unknown but may involve chelation with polyvalent ions in antacids or enhanced drug solubility induced by an increase in gastric pH, or both. The interaction has been reported with magnesium/aluminum-containing antacids.

MANAGEMENT: Patients treated with oral mycophenolic acid who require an antacid or antacid-containing preparation (e.g., didanosine buffered tablets or pediatric oral solution) should separate the administration times of the medications by at least two hours.

References

"Product Information. Myfortic (mycophenolic acid)." Novartis Pharmaceuticals, East Hanover, NJ.
"Product Information. CellCept (mycophenolate mofetil)." Roche Laboratories, Nutley, NJ.
Lipsky JJ "Mycophenolate mofetil." Lancet 348 (1996): 1357-9
Bullingham R, Shah J, Goldblum R, Schiff M "Effects of food and antacid on the pharmacokinetics of single doses of mycophenolate mofetil in rheumatoid arthritis patients." Br J Clin Pharmacol 41 (1996): 513-6

Mycophenolate mofetil oral/injection

Generic Name: mycophenolate mofetil

Brand name: Cellcept, Myfortic, MMF

Synonyms: Mycophenolate mofetil (oral/injection), Mycophenolate

What is Mycophenolate mofetil oral/injection?

Titralac

Generic Name: calcium carbonate

Brand name: Alka-Mints, Alkets, Alkums, Amilac, Amitone, Cal Oys, Cal-Gest, Calcarb, Calci Mix, Calci-Chew, Calcitab, Caltrate, Caltro, Chooz, Dicarbosil, Equilet, Mylanta Child, Nephro Calci, OsCal 500, Oysco 500, Oyst Cal, Oyst Cal 500, Oyster Cal 500, Oyster Calcium, Oyster Shell, Oyster Shell Calcium 500, Rolaids Sodium Free, Super Calcium, Titralac, Tums, Tums 500, Tums E-X, Tums Ultra, Cal-Mint, Calci Mix, Os-Cal 500, Calcium Concentrate, Oyster, Oyster Cal, Calcium Oyster, Calcium Liquid Softgel, Maalox Quick Dissolve, Maalox Quick Dissolve Maximum Strength, Ultra Mylanta Calci Tabs, Extra Strength Mylanta Calci Tabs, Os-Cal, Surpass, Surpass Extra Strength, Icar Prenatal Chewable Calcium, Tums Extra Strength, Maalox Quick Dissolve Extra Strength, Calcium Oyster Shell, Maalox Antacid Barrier, Rolaids Soft Chew, Pepto Children's, Maalox Regular Strength, Maalox Children's, Tums Kids, Tums QuikPak, Calci-Mix, Alcalak, Tums Smoothies, Tums Chewy Bites, Tums Chewy Delights, Tums Sugar-Free

Synonyms: n.a.

What is Titralac?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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