Mycophenolate Suspension and Welchol (Colesevelam Oral Suspension)
Determining the interaction of Mycophenolate Suspension and Welchol (Colesevelam Oral Suspension) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Colesevelam may interfere with the absorption of mycophenolate mofetil, which may make the medication less effective in treating your condition. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: Coadministration with bile acid sequestrants or activated charcoal may decrease the bioavailability of mycophenolic acid. In 12 healthy volunteers, pretreatment with cholestyramine (4 g three times a day for 4 days) decreased the systemic exposure (AUC) of mycophenolic acid (from mycophenolate mofetil 1.5 g single dose) by 40% compared to administration of mycophenolate mofetil alone. The proposed mechanism is interruption of enterohepatic recirculation due to binding of recirculating mycophenolic acid glucuronide (a product of the first-pass metabolism of mycophenolic acid) with cholestyramine in the intestine. Some degree of enterohepatic recirculation is also anticipated following intravenous administration of mycophenolate mofetil, thus the interaction is not limited to the oral route.
MANAGEMENT: Given the risk of organ rejection associated with inadequate immunosuppressant blood levels, mycophenolic acid products should not be administered with cholestyramine or other agents that may interfere with enterohepatic recirculation or bind bile acids (e.g., activated charcoal).
- "Product Information. CellCept (mycophenolate mofetil)." Roche Laboratories, Nutley, NJ.
Generic Name: mycophenolate mofetil
Brand name: Cellcept, Myfortic, MMF
Synonyms: Mycophenolate mofetil (oral/injection), Mycophenolate
Generic Name: colesevelam
Brand name: Welchol, Colesevelam Hydrochloride
Synonyms: Welchol
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Mycophenolate Suspension-Welchol (Colesevelam Tablets)
- Mycophenolate Suspension-Wellbaby DHA
- Mycophenolate Suspension-Wellbutrin
- Mycophenolate Suspension-Wellbutrin SR
- Mycophenolate Suspension-Wellbutrin Tablets
- Mycophenolate Suspension-Wellbutrin XL
- Welchol (Colesevelam Oral Suspension)-Mycophenolate Tablets
- Welchol (Colesevelam Oral Suspension)-Mycophenolate Tablets Delayed Release
- Welchol (Colesevelam Oral Suspension)-Mycophenolic acid
- Welchol (Colesevelam Oral Suspension)-Mycophenolic Acid Delayed-Release Tablets
- Welchol (Colesevelam Oral Suspension)-Mycophenolic Acid Tablets
- Welchol (Colesevelam Oral Suspension)-Mycostatin (Nystatin Oral Suspension)