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Myfortic and Probenecid Tablets

Determining the interaction of Myfortic and Probenecid Tablets and the possibility of their joint administration.

Check result:

Myfortic <> Probenecid Tablets

Relevance: 13.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using mycophenolic acid together with probenecid may increase the effects of mycophenolic acid. Contact your doctor if you experience increased side effects or if your condition changes. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Animal studies have shown that coadministration with probenecid results in a 2-fold increase in the systemic exposure (AUC) of mycophenolic acid and a 3-fold increase in the AUC of mycophenolic acid glucuronide, an inactive metabolite. The proposed mechanism is competition of these agents for renal tubular secretion.

MANAGEMENT: Caution is advised if mycophenolic acid products must be used concomitantly with probenecid. The dosage of one or both drugs may require adjustments.

References

"Product Information. CellCept (mycophenolate mofetil)." Roche Laboratories, Nutley, NJ.

Myfortic

Generic Name: mycophenolic acid

Brand name: Myfortic

Synonyms: n.a.

What is Myfortic?

Probenecid Tablets

Generic Name: probenecid

Brand name: Benemid

Synonyms: Probenecid

What is Probenecid Tablets?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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