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Mylanta Supreme and Sporanox

Determining the interaction of Mylanta Supreme and Sporanox and the possibility of their joint administration.

Check result:

Mylanta Supreme <> Sporanox

Relevance: 06.12.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using calcium carbonate together with itraconazole may decrease the effects of itraconazole. Separate the dose of calcium carbonate and itraconazole by two or more hours. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

ADJUST DOSING INTERVAL: The dissolution of itraconazole requires an acidic environment. Antacids and some aluminum, calcium, or magnesium containing salts decrease the acidity of the stomach and can reduce the bioavailability and subsequent therapeutic effect of itraconazole.

MANAGEMENT: Separation of doses by two or more hours is recommended.

References

Carlson JA, Mann HJ, Canafax DM "Effect of pH on disintegration and dissolution of ketoconazole tablets." Am J Hosp Pharm 40 (1983): 1334-6
Brass C, Galgiani JN, Blaschke TF, et al "Disposition of ketoconazole, an oral antifungal, in humans." Antimicrob Agents Chemother 21 (1982): 151-8
Katz HI "Drug interactions of the newer oral antifungal agents." Br J Dermatol 141 (1999): 26-32
"Product Information. Sporanox (itraconazole)." Janssen Pharmaceutica, Titusville, NJ.
Van der Meer JW, Keuning JJ "The influence of gastric acidity on the bio-availability of ketoconazole." J Antimicrob Chemother 6 (1980): 552-4

Mylanta Supreme

Generic Name: calcium carbonate / magnesium hydroxide

Brand name: Mi-Acid Double Strength, Mylanta Supreme, Rolaids, Fast Acting Mylanta, Mylanta Ultra, Mylanta Gelcap, Rolaids Extra Strength, Masanti Supreme

Synonyms: n.a.

What is Mylanta Supreme?

Sporanox

Generic Name: itraconazole

Brand name: Sporanox, Onmel, Sporanox PulsePak, Tolsura

Synonyms: n.a.

What is Sporanox?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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